If you’re a fan of The Binding of Isaac: Rebirth, then you’ve surely heard of the D6 – one of the most iconic items in the game. This multi-functional costume gives you the power to flip the items you find in the game into something potentially better. It’s a dream come true for any player who wants to customize their runes into the perfect configuration.
The Binding of Isaac Rebirth How To Unlock D6
D6 is an active item that allows you to flip an item on the pedestal. For example, if you find something that is completely useless to you, you can use D6 to draw something else.
D6 is only available for Isaac’s character and requires a few specific conditions. Here’s the full process:
1 – Beat Mom’s Heart
First of all, you need to get to the point where you regularly unlock new stages. Defeating Mom’s Heart in The Binding of Isaac: Rebirth several times allows you to discover more locations.
2- Unlock and defeat Boss Satan (Sheol).
You must complete the run by going down to Sheol (you can do this by finding the entrance to Sheol after fighting Mom’s Heart). Fighting Satan is a challenge, but with the right build it is fully doable.
3 – Defeat Satan by playing as Isaac
This is a key step – playing as Isaac, you must defeat Satan in Sheol.
Once this is completed, the D6 rune will be unlocked as an active starting item for Isaac. This allows you to manipulate your build from the first floors, drastically increasing your chances for powerful and satisfying runes. Combining D6 with the right items (such as Battery, Habit or 9 Volt) can turn the game into a real reroll festival.
CONCLUSION
The D6 is one of the most iconic items in The Binding of Isaac: Rebirth, allowing Isaac to reroll pedestal items into potentially better ones. To unlock it, you must defeat Satan in Sheol while playing as Isaac, which requires unlocking Sheol by beating Mom’s Heart multiple times. Once obtained, the D6 transforms Isaac’s runs, enabling powerful item combinations and endless customization opportunities.
